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KMID : 0942820110100020103
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Journal of Korean Brain Tumor Society
2011 Volume.10 No. 2 p.103 ~ p.109
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An Image Study of Malignant Glioma Model with Diffraction Enhanced Imaging Computed Tomography
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Yoo Je-Chul
Lee Sang-Pyung
Kim Jong-Ki
Choi Ki-Hyun
Yeo Hyung-Tae
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Abstract
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Objective: Glioblastoma is the most common malignant brain tumor, accounting for 2-15% of intracranial tumors and one half of primary brain tumors, and it is one of the most malignant brain tumor due to its aggressive biological behavior. In order to detect the true glioblastoma tumor margin including infiltrated tumor components in the peritumoral edema zone, Diffraction Enhanced Imaging (DEI) technique was used.
Materials and Methods: The orthotopic brain tumor models were made in Sprague Dawley rats using C6 tumor cell line. The whole brain was taken out as ex vivo model using cardiac perfusion with a fixing agent after confirming apparent evidence of tumor development with peritumoral edema in the brain of model by MR images. DEI-CT was acquired at 35 KeV monochromatic X-ray from Photon Factory Synchrotron facility. The reconstructed 2D/3D images were analyzed.
Results: In glioma model, distinction among necrosis, typical ring-shaped viable tissue, edema and healthy tissue were clearly observed in the region of the frontal lobe in front of caudate nucleus. In addition, DEI-CT images of the normal cerebellum showed more apparent contrast between the white and gray matter than conventional absorption-based CT images.
Conclusion:Higher-resolution imaging of the tumor cells could be obtained with DEI-CT than conventional method. It could be useful in the diagnosis, treatment planning, and determination of the effectiveness of treatment in malginant glioma.
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KEYWORD
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Brain tumor, Diffraction-enhanced imaging (DEI), Synchrotron X-ray, Tumor infiltration
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